Department of Chemistry
Wright-Rieman Labs, Busch Campus
Piscataway, NJ 08854
Biopolymer conformation and properties
The primary research goal of our research group is to understand the three-dimensional structure and the structure-dependent properties of the nucleic acids in terms of their constituent chemical architecture. Problems of current interest include: (1) new computational methods to generate and analyze constrained configurations such as the loops and hairpins of RNA, the cruciform junctions of DNA, and the closed, superhelical arrangements of the double helix; (2) computer simulation of the DNA helix to random coil transition; (3) improved procedures to analyze local structural morphology and to model the effects of base sequence and electrostatics on macromolecular flexibility; (4) new computational models of protein-nucleic acid interactions.