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Carman, George M.

George M. Carman
Board of Governors Professor

Center for Lipid Research
Institute of Food, Nutrition, and Health, Room 12
School of Biological and Environmental Sciences
Rutgers University
61 Dudley Road
New Brunswick, NJ 08901-8520
(848) 932-0267
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Regulation of Phospholipid Metabolism/Signaling in Yeast

Dr. George M. Carman is the Board of Governors Professor of Food Science and Founding Director of the Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, & Health. Research in our laboratory utilizes molecular genetics and biochemical approaches to study the regulation of phospholipid metabolism in the yeast Saccharomyces cerevisiae. Phospholipids are essential molecules that contribute to the structural definition of cell membranes, and participate in the regulation of cellular processes as signaling molecules and as reservoirs of lipid messengers. Our laboratory has made significant contributions to the understanding of phospholipid synthesis in yeast through the purification and characterization of several enzymes, and through the isolation and characterization of key genes. The laboratory has played a major role in the discovery that the expression of phospholipid synthesis enzymes is regulated by phospholipid precursors (e.g., inositol, choline, ethanolamine, and serine) and the mineral zinc; and that key enzymes are regulated by membrane (e.g., phospholipids, sphingolipids) - and cytosolic (e.g., inositol, serine, ATP, CTP) -associated components, by covalent modifications via protein kinases and protein phosphatases, and by proteasome-mediated degradation. These forms of enzyme regulation have profound effects on membrane phospholipid composition and cell physiology, and have important implications for understanding the molecular basis for lipid-based diseases (e.g., obesity, lipodystrophy, diabetes, and heart disease).

Publications

Contact Us

Division of Life Sciences Graduate Program Office
Rutgers, The State University of New Jersey
Nelson Lab-604 Allison Rd
Piscataway, NJ 08854
Phone: 848.445.9517
gradoffice@dls.rutgers.edu