James S. Goydos
Robert Wood Johnson Medical School
Department of Surgery
Cancer Institute of New Jersey
195 Little Albany Street, Room 3003
New Brunswick, NJ 08854
Melanoma and soft tissue oncology
The goals of this project are to examine the relationship of known prognositic variables in primary melanomas and level of Grm1 expression, to perform in vivo testing of anti-glutamate therapies in melanoma xenograft models, and to determine if suppression of Grm1 signaling affects migration and invasion, uPA expression, and vasculogenic mimicry in aggressive melanoma cell lines.