Robert Wood Johnson Medical School
Dept of Surgery/Division of Urology
The Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, N.J. 08901
Roles of transforming growth factor- β and bone morphongenetic proteins in prostate cancer cells
A focus of current studies in our laboratory lies in understanding the role of tumor-derived bone morphogenetic proteins (BMPs) and TGF-beta on the local immune response, especially macrophages. Our findings suggest that BMPs and TGF-beta are major regulators of tumor-associated macrophages. Based on our findings, we are currently investigating various small molecule inhibitors as well as adoptive cell therapies to block the effect of tumor-derived BMPs and TGF-beta on tumor-associated macrophages in prostate cancer.