Robert Wood Johnson Medical School
Dept. of Neuroscience & Cell Biology
675 Hoes Lane
Piscataway, NJ 08854
How nitric oxide and its second messenger cyclic GMP serve as a "brake" on myocardial function and how this changes in disease, II. The relationship between excitatory amino acid receptors and cerebral oxygen supply and consumption balance and the changes in disease
In the brain, excitatory amino acids, such as glutamate, increase cerebral oxygen consumption. The relative importance of the various glutamate receptors in the control of cerebral metabolism is not known. Activation of these receptors also affects cerebral blood flow. How the relationship between cerebral oxygen supply and consumption is affected by these receptors is not known. We also wish to determine the importance of the various receptor subtypes in the control of cerebral metabolism during stroke. Excess activation of these receptors leads to excitotoxicity.