Robert Wood Johnson Medical School
Department of Pediatrics
CABM - Room 206
679 Hoes Lane
Piscataway, NJ 08854
Visit the Xiang Lab
Molecular bases of sensorineural development, transcriptional regulation of retinal and inner ear development
My laboratory utilizes two general approaches to understand the biological roles that a transcription factor gene plays during vertebrate neurogenesis. One is a loss-of-function approach involving targeted gene disruption in mouse embryonic stem (ES) cells to produce mice deficient for the gene of interest. The other is a gain-of-function approach involving plasmid/retrovirus-mediated overexpression of the gene of interest in the chick and mouse embryonic tissues. These complementary approaches have allowed us to identify a number of transcription factors including Foxn4, Barhl and Brn3 as crucial regulatory factors that are required for fate commitment, differentiation and/or survival of various sensory cells and neurons.