Dept. of Ecology, Evolution & Natural Resources
Foran Hall, Room 102
School of Env & Biol Sciences
New Brunswick, NJ 08903
Algal evolution, genomics, endosymbiosis, red tides, plastids, tree of life
Key questions that drive ongoing research in our lab are:
1. How do photosynthetic endosymbionts become organelles and how does intracellular gene transfer from the endosymbiont shape nuclear genome evolution?
The long-term goal is to explain the origin of one of the fundamental characters that define eukaryotes, intracellular organelles of foreign origin.
2. What is the origin of the processes and molecular machines that are essential for the integration of plastid function with overall cellular function?
Using the expanding genome data, bioinformatics, and experimental methods, provide a detailed model of the integration of the plastid endosymbiont into "host" cell biochemistry.
3. Which environmental and genetic factors control formation of harmful algal blooms (e.g., red tides) and which genes comprise the saxitoxin biosynthetic pathway in the toxic dinoflagellate Alexandrium tamarense?
The long-term goal is to predict and potentially ameliorate red tides that devastate coastal fisheries worldwide.
4. How do the "simple" genomes of unicellular algae respond to the highly complex, changing aquatic environments in which they live?
Using comparative genomics and analysis of small RNAs in model algae we seek to understand how variation in the genome and gene expression confers adaptation to different environmental niches.
5. What is the framework of the eukaryotic tree of life?
Using phylogenetic and phylogenomic approaches infer an accurate and broadly sampled tree of life for microbial eukaryotes.