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Yakoby, Nir


Nir Yakoby
Associate Professor
Rutgers University
Department of Biology
Science Building
315 Penn St.
Camden, NJ 08102
(856) 225-6150
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Signaling dynamics, patterning and morphogenesis

The main interest of our laboratory is to elucidate mechanisms of cell fate determination by tissue patterning that is regulated by morphogen gradients. We focus on the conserved Bone Morphogenetic Protein (BMP) pathway and use fruit fly oogenesis as a model system. Specifically, we use Drosophila egg formation to monitor the dynamics of BMP signaling in developing egg chambers. The egg chamber is the precursor of the mature egg, and the follicle cells (FCs) surrounding the developing oocyte are responsible for eggshell formation. Eggshell imprints reflect earlier patterning events in the FCs and provide an excellent output for the interpretation of changes in patterning caused by genetic perturbations. Mechanisms found in our experimental work will be used to develop models, accommodating multiple components of signaling networks, to predict which component can account for the evolution of eggshell morphological traits. Current projects include the characterization of multiple signaling components controlling the dynamics of BMP signaling, and the determination whether the divergence of signaling components can account for the diversity of eggshell morphologies between different fly species.



Contact Us

Division of Life Sciences Graduate Program Office
Rutgers, The State University of New Jersey
Nelson Lab-604 Allison Rd
Piscataway, NJ 08854
Phone: 848.445.9517