Chung S. Yang
Department of Chemical Biology
Ernest Mario School of Pharmacy
164 Frelinghuysen Road
Piscataway, NJ 08854-0789
Molecular mechanisms of carcinogenesis and its prevention
The research program is focused on studying the molecular mechanisms of carcinogenesis and designing strategies and agents for the prevention of cancer. Specific projects involve: 1) characterizing the molecular alterations at different stages of esophageal cancer development in animal models and human tissues; 2) studying inflammation, carcinogenesis, and cancer prevention in animal models for esophageal adenocarcinoma and ulcerative colitis-associated colon carcinogenesis; 3) studying the cancer preventive activity of tea, curcumin, genistein, and other dietary constituents, and combinations thereof with synthetic compounds in animal models for lung, oral, esophageal, intestinal, and colon cancers. The molecular mechanisms of action as well as the metabolism and bioavailability of these compounds are being studied in cell lines, animal models, and humans.