Robert Wood Johnson Medical School
Environmental & Occupational Medicine
Environmental and Occupational Health Sciences Institute
170 Freylinghuysen Road, Room 426
Piscataway, NJ 08854
Mammary carcinogenesis, Lung Carcinogenesis, Mechanisms of toxicity, Genetic susceptibility, Toxicogenomics, Tumor suppressor genes, Functional genomics, Signal transduction, Transcriptional regulation, Mutagenesis
Dr. Zarbl's research has focused largely on toxicogenomics and functional genomics, carcinogenesis, molecular and cellular biology, and toxicology. Specifically this has included work to understand molecular mechanisms of chemical carcinogenesis and the genetic basis for differential susceptibility to mammary carcinogenesis using both animal and in vitro model systems. Studies in the rat model have included analysis of oncogene activation, mechanisms of signal transduction, and genetic linkage analysis to identify mammary tumor suppressor genes. He has also used toxicogenomics to dissect mechanisms of mechanism carcinogenesis, tumor progression and chemoprevention. His studies in the area of toxicogenomics include the development and application of standards for DNA microarray experiments, and phenotypic anchoring of response of human cells, model organisms (yeast) and target organs (rodents) to toxicants, providing insights into dose and temporal responses, as well as mechanisms of action. He is also actively involved in technology development, including his patented work on RNAi and its application to the development of novel platforms for functional genomics (with Engineering Arts, Inc.).