Abdelfattah El Ouaamari
Robert Wood Johnson Medical School
Department of Medicine
The Child Health Institute of NJ
89 French Street
New Brunswick, NJ 08901
Organ Crosstalk, Energy Homeostasis, Pancreas, Insulin-Producing β Cells, Diabetes
Several organ systems cross-talk with the pancreatic islet cells to maintain whole-body glucose homeostasis—particularly in the settings of pre-diabetes and insulin resistance. However, the nature and the identity of the molecules mediating this inter-organ metabolic communication remain to be determined. Our laboratory employs a multidisciplinary approach to identify local, systemic and neuronal signals regulating the number and the function of pancreatic islet insulin-producing β cells in mouse and human models of obesity and diabetes.