C. elegans cilia development, morphogenesis, and function: a human disease model
The Barr lab uses the nematode C. elegans to study fundamental questions in molecular genetics and cell biology (ciliogenesis, ciliary transport, and most recently, ciliary extracellular vesicles) and to model human genetic diseases of the kidney and cilia. We consistently tackle major important problems that are biomedically relevant. Many of the genes and pathways we study control C. elegans behaviors, therefore we are also interested in neurogenetics and neuroplasticity. Our studies have guided research into autosomal dominant polycystic kidney disease and other ciliopathies. Our research has unlocked insights into three exciting new areas in the Barr lab: ciliary specialization, extracellular vesicles (EVs), and stress-induced neuronal restructuring.