Robert Wood Johnson Medical School
Department of Pharmacology
Research Tower, Room 400
675 Hoes Lane
Piscataway, NJ 08854-5635
FAX - 5038
Pathogenesis and intervention of sexually transmitted
1. Chlamydial Cellular and Molecular Parasitology
Chlamydiae are Gram-negative eubacteria that replicate strictly inside
eukaryotic cells. Chlamydia trachomatis is the most prevalent cause
of sexually transmitted infection and preventable blindness. Though C.
trachomatis infection is mostly asymptomatic or manifests only mild
urogenital symptoms, it often results in devastating complications including
infertility, chronic pelvic pain, ectopic pregnancy, premature birth and
arthritis. C. pneumoniae is a common pathogen in the respiratory
system and is also highly significant contributory factor of
atherosclerosis. We are interested in identifying novel host factors that
control chlamydial infection.
2. Development of New Prophylaxes and Therapies for Sexually Transmitted
We have identified peptide deformylase as an essential enzyme for chlamydial
growth. We are characterizing this enzyme and exploring its inhibition for
the prevention and treatment of chlamydial diseases and other sexually
transmitted infections including gonorrhea. We also attempt to identify
novel antimicrobials and investigate the underlying targeting mechanism.