Robert Wood Johnson Medical School
Dept. of Biochemistry & Molecular Biology
Research & Public Health Bldg.
Piscataway, NJ 08854
FAX - 5038
the Jacinto Lab
Signal transduction, cancer, insulin, metabolism, T lymphocytes
Research in my lab aims to understand how nutrients and growth factors control intracellular signaling pathways and how these pathways are coupled to cellular metabolism. We specifically focus on the mechanistic target of rapamycin (mTOR) signaling pathway and how it plays a role in cancer metabolism, diabetes and T cell biology. Our goal is to understand how cells rewire metabolic processes in response to genetic and environmental changes and how we can manipulate this reprogramming process to improve immunotherapy and develop more effective therapeutic strategies for cancer and other metabolic disorders. We use both mammalian cell and mouse models and employ techniques including proteomics/genomics, metabolomics, flow cytometry, biochemical and cell biology techniques.