The research in my laboratory focuses on understanding the molecular aspects of chromatin-remodeling and circadian rhythms. Circadian rhythms control developmental, behavioral and physiological processes by regulating gene expression on a daily basis. Chromatin-remodeling is an integral part of transcriptional regulation and is proving to be one of the major determinants required for the proper timing and amplitude of clock-gene expression. Understanding the molecular mechanisms underlying transcriptional regulation and chromatin-remodeling in clock-regulated gene expression is paramount to understanding the progression of numerous diseases including cancer. My lab uses the highly-tractable model eukaryote Neurospora crassa in combination with biochemical, genetic and genome-wide studies to understand the molecular mechanisms of chromatin-remodeling in clock function.
Faculty
- William J. Belden
- Associate Professor
- Department: Department of Animal Sciences
- Phone: 1.8489325617
- Email: beldenwj@rutgers.edu
- Rutgers University
- School of Environmental & Biological Sciences
- Foran Hall, Room 326
- 59 Dudley Road
- New Brunswick, NJ 08901-8525
- Key Words: Chromatin-remodeling, Circadian rhythms, Non-coding RNA
