We are interested in gametogenesis, the process by which germ cells undergo meiosis and differentiate to generate gametes. We also strive to understand how defects in gametogenesis lead to infertility, miscarriage and birth defects. To this end, we use genetic, molecular and genomic approaches in mouse to study the regulation of gametogenesis.
The current focus of our research is on understanding two fundamental aspects of mammalian gametogenesis:
1) Control of the dynamic gene expression program that drives gametogenesis and roles of post-transcriptional RNA regulation in the orchestration of meiotic events.
2) Genome defense mechanisms that repress retrotransposons in the germline and their coordination with other chromosomal processes, such as meiotic recombination.