Isaac Kim
Department: Department of Surgery/Division of Urology
Phone: 1.7322352043
Email: kimiy@cinj.rutgers.edu
Robert Wood Johnson Medical School
The Cancer Institute of New Jersey, Room 4535
195 Little Albany Street
New Brunswick, N.J. 08901
Key Words: Roles of transforming growth factor- β and bone morphongenetic proteins in prostate cancer cells

The primary focus of our laboratory is the study of the tumor host interaction with the ultimate goal being the design of new and effective therapy for prostate cancer. The interaction between the host immune system and tumor is a multifaceted one with the generation of productive immunity requiring the cooperation of immune cells from multiple lineages. Further complicating the system, tumor cells themselves can produce immune suppressive factors.

A focus of current studies in our laboratory lies in understanding the role of tumor-derived bone morphogenetic proteins (BMPs) and TGF-beta on the local immune response, especially macrophages. Our findings suggest that BMPs and TGF-beta are major regulators of tumor-associated macrophages. Based on our findings, we are currently investigating various small molecule inhibitors as well as adoptive cell therapies to block the effect of tumor-derived BMPs and TGF-beta on tumor-associated macrophages in prostate cancer.