O - P

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  • Mehdi Pirouz
  • Assistant Professor
  • Department: Department of Biochemistry & Molecular Biology
  • Phone: 1.8484459835
  • Email: mp1771@cabm.rutgers.edu
  • Rutgers University
  • CABM - 679 Hoes Lane
  • Room 306
  • Piscataway, NJ 08854
  • Key Words: Understanding the role of RNA metabolism in Stem Cells, Development, and Disease
  • Lab Site URL

 

Noncanonical Regulation of mRNA Translation

Regulation of mRNA translation is crucial to cellular homeostasis, development, and growth. The failure to tightly regulate mRNA translation causes several diseases including developmental disorders and cancer. Canonical regulation of mRNA translation ensures the fidelity of mRNA initiation, elongation, and termination. However, these canonical pathways cannot explain several aspects of mRNA translation in cells, for example: 1) how mRNA modifications contribute to its fate and function; 2) how organelle-coupled mRNA translation at the endoplasmic reticulum (ER) and mitochondria are regulated; 3) how the information in the 5’- and 3’-untranslated regions (UTRs) affects mRNAs translation outcome. Also, how these pathways contribute to cellular homeostasis or dysregulation in human diseases in not fully understood. This highlights the importance of studying noncanonical mRNA translation pathways.

We apply a diverse set of contemporary molecular, cellular, and in vivo approaches, including RNA and protein biochemistry, RNA-sequencing, ribosome profiling, CRISPR- and chemical-screening, and microscopy to provide mechanistic insights into these pathways. We utilize stem cell differentiation, cancer cells, and genetic mouse models to unravel the physiological significance of noncanonical mRNA translation pathways in the context of development and disease.

Publications

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  • Timothy Otto
  • Professor
  • Department: Department of Psychology
  • Phone: .8484458881
  • Email: timothy.otto@rutgers.edu
  • Rutgers University
  • Piscataway, NJ 08854
  • Key Words: Biological basis of memory formation and storage in the mammalian brain

Read more: Otto, Timothy

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  • Mark R. Plummer
  • Professor
  • Department: Department of Cell Biology and Neuroscience
  • Phone: 1.8484450422
  • Email: mplummer@dls.rutgers.edu
  • Rutgers University
  • Nelson Lab. Room D412
  • Piscataway, NJ 08855-1059
  • Key Words: Regulation of synaptic transmission

Read more: Plummer, Mark R.

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  • Daniel Pilch
  • Professor
  • Department: Department of Pharmacology
  • Phone: 1.7322353352
  • Email: pilchds@rwjms.rutgers.edu
  • Robert Wood Johnson Medical School
  • RWJMS. Room 422A
  • Piscataway, NJ 08854
  • Key Words: Targeting cell division proteins for the treatment of multidrug-resistant bacterial infections / Identifying new antibiotics and drug combinations against clinically important bacterial pathogens / Study bacterial cell division using a newly developed fluorescence-based technology

Read more: Pilch, Daniel

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  • Henrik Pedersen
  • Professor
  • Department: Department of Chemical & Biochemical Engineering
  • Phone: 1.8484454795
  • Email: hpederse@rutgers.edu
  • Rutgers University
  • 68 Brett Road
  • Piscataway, NJ 08854
  • Key Words: Plant cell culture, chemical and biochemical fiber optic sensors, applications of biophotonics in bioprocess technology

Read more: Pedersen, Henrik