• Tulsi Patel
  • Tulsi Patel
  • Assistant Professor
  • Department: Department of Neuroscience and Cell Biology
  • Program(s): Cell and Developmental Biology Graduate Program
  • Major Research Interest(s): Stem Cells, Neurobiology
  • Research Organisims: Mice
  • Rotating Faculty
  • Phone: 1.7322355089
  • Rutgers University
  • School of Public Health
  • Lab: Rm 456 / Office: Rm 457A
  • 638 Hoes Lane West
  • Piscataway, NJ 08854
  • Key Words: Neuronal maturation, Stem cell derived neurons, Transcriptional regulation, Temporal gene expression changes in post-mitotic neurons
  • Lab Site URL

Nervous systems mature over long time spans. Even though we are born with most of our neurons, it takes years to fully develop mature behaviors like movement, coordination, and decision-making. Maturing and fully mature neurons also become susceptible to diseases like schizophrenia, Alzheimer’s, and Amyotrophic Lateral Sclerosis (ALS) which do not affect young neurons, even in individuals who carry causative genetic mutations.

Our lab studies the changes that individual neurons undergo as the nervous system matures, both in vivo in mice and in vitro in stem cell-derived neurons. We are interested in a wide range of questions, such as: What are the transcriptional and chromatin regulatory mechanisms that control maturation? How can stem cell derived neurons acquire mature states in culture? Why are mature neurons more susceptible to neurological diseases such as ALS, Alzheimer’s, and Parkinson’s than nascent neurons.