• Loren Runnels
  • Loren Runnels
  • Professor
  • Department: Department of Pharmacology
  • Program(s): Cell and Developmental Biology Graduate Program, Cellular and Molecular Pharmacology Graduate Program, Microbiology and Molecular Genetics Graduate Program, Physiology and Integrative Biology Graduate Program
  • Major Research Interest(s): Biochemistry, Stem Cells
  • Phone: 1.7322354593
  • Robert Wood Johnson Medical School
  • Research Tower, Fourth Floor, Room 402
  • 675 Hoes Lane West
  • Piscataway, NJ 08854
  • Key Words: Cancer, stem cells, development, cell death, signal transduction, ion transport, magnesium, calcium

The focus of my laboratory is to understand the role that ions such as calcium, magnesium, and zinc play in living organisms. We are currently focused on investigating the function of the TRPM7 and TRPM6 ion channels, which transport these divalent cations, and their contribution to human health and disease. Recently, we identified members of the CNNM family (CNNM1-4) as binding proteins of TRPM7. CNNMs are regulated by ARL15 and PRL proteins. We are currently studying the impact of CNNMs, PRLs, and ARL15 on TRPM7 and TRPM6 function and how these molecules work in concert to contribute to physiological and pathological processes, including embryonic development, cancer, and oxidative stress in neurons during ischemic stroke.  This laboratory employs a multi-disciplinary approach to study the function of these unusual macromolecules. Among the many tools our laboratory uses are stem cells, fluorescence microscopy, biochemistry, and molecular biology.