How do bacteria sense changes in their environment? How do they respond and adapt to different stresses such as exposure to antimicrobial agents?
The Yadavalli lab is interested in understanding the regulatory pathways that underlie stress response in bacteria and how these pathways contribute to the emergence of antimicrobial resistance. In addition, my lab will explore the biochemical functions of the growing number of understudied small proteins - a challenging yet exciting new area in bacterial gene regulation networks. We use a variety of tools including classical genetics, microbiology and biochemistry, high throughput sequencing as well as proteomics to answer fundamental questions in bacterial stress response.