Graduate Program in Cell & Developmental Biology

Graduate Program in Cell & Developmental Biology

  • Patel, Tulsi

    • Tulsi Patel
    • Tulsi Patel
    • Assistant Professor
    • Department: Department of Neuroscience and Cell Biology
    • Program(s): Cell and Developmental Biology Graduate Program
    • Major Research Interest(s): Stem Cells, Neurobiology
    • Research Organisims: Mice
    • Rotating Faculty
    • Phone: 1.7322355089
    • Rutgers University
    • School of Public Health
    • Lab: Rm 456 / Office: Rm 457A
    • 638 Hoes Lane West
    • Piscataway, NJ 08854
    • Key Words: Neuronal maturation, Stem cell derived neurons, Transcriptional regulation, Temporal gene expression changes in post-mitotic neurons
    • Lab Site URL
  • Pintar, John E

    • John E Pintar
    • John E Pintar
    • Professor
    • Department: Department of Neuroscience & Cell Biology
    • Phone: 1.7322354250
    • Robert Wood Johnson Medical School
    • RWJ-SPH Bldg. Room 359
    • 683 Hoes Lane
    • Piscataway, NJ 08854
    • Key Words: Genetic and microarray analysis of endogenous opioid systems; insulin-like growth factor systems in development and cancer; post-translational processing enzymes
  • Pirouz, Mehdi

    • Mehdi Pirouz
    • Assistant Professor
    • Department: Department of Biochemistry & Molecular Biology
    • Program(s): Cell and Developmental Biology Graduate Program
    • Phone: 1.8484459835
    • Rutgers University
    • CABM - 679 Hoes Lane
    • Room 306
    • Piscataway, NJ 08854
    • Key Words: Understanding the role of RNA metabolism in Stem Cells, Development, and Disease
    • Lab Site URL

     Noncanonical Regulation of mRNA Translation

    Regulation of mRNA translation is crucial to cellular homeostasis, development, and growth. The failure to tightly regulate mRNA translation causes several diseases including developmental disorders and cancer. Canonical regulation of mRNA translation ensures the fidelity of mRNA initiation, elongation, and termination. However, these canonical pathways cannot explain several aspects of mRNA translation in cells, for example: 1) how mRNA modifications contribute to its fate and function; 2) how organelle-coupled mRNA translation at the endoplasmic reticulum (ER) and mitochondria are regulated; 3) how the information in the 5’- and 3’-untranslated regions (UTRs) affects mRNAs translation outcome. Also, how these pathways contribute to cellular homeostasis or dysregulation in human diseases in not fully understood. This highlights the importance of studying noncanonical mRNA translation pathways.

    We apply a diverse set of contemporary molecular, cellular, and in vivo approaches, including RNA and protein biochemistry, RNA-sequencing, ribosome profiling, CRISPR- and chemical-screening, and microscopy to provide mechanistic insights into these pathways. We utilize stem cell differentiation, cancer cells, and genetic mouse models to unravel the physiological significance of noncanonical mRNA translation pathways in the context of development and disease.

    Publications

  • Plummer, Mark R.

    • Mark R. Plummer
    • Mark R. Plummer
    • Professor
    • Department: Department of Cell Biology and Neuroscience
    • Program(s): Cell and Developmental Biology Graduate Program
    • Phone: 1.8484450422
    • Rutgers University
    • Nelson Lab. Room D412
    • Piscataway, NJ 08855-1059
    • Key Words: Regulation of synaptic transmission
  • Radovick, Sally

    • Sally Radovick
    • Sally Radovick
    • Professor
    • Department: Department of Pediatrics
    • Phone: 1.7322359524
    • Robert Wood Johnson Medical School
    • Clinical Academic Bldg
    • 125 Paterson Street
    • New Brunswick, NJ 08901
    • Key Words: Pediatric growth and development disorders
    • Lab Site URL
  • Rasin, Mladen-Roko

    • Mladen-Roko Rasin
    • Mladen-Roko Rasin
    • Associate Professor
    • Department: Department of Neuroscience & Cell Biology
    • Phone: 1.7322354553
    • Robert Wood Johnson Medical School, Room 343A
    • 475 Hoes Lane
    • Piscataway, NJ 08854
    • Key Words: Molecular and cellular mechanisms of neocortical circuit formation
  • Rongo, Christopher

    • Christopher Rongo
    • Christopher Rongo
    • Professor
    • Department: Department of Genetics
    • Phone: 1.8484450955
    • Rutgers University
    • Waksman Institute, Room 124
    • Piscataway. NJ 08854-0759
    • Key Words: C. elegans, mitochondria, learning and memory, neurons, synapses, hypoxia, ischemia, ubiquitination, proteasome, proteostasis, autophagy, mitophagy
    • Lab Site URL
  • Roth, Charles M

    • Charles M. Roth
    • Charles M. Roth
    • Professor
    • Department: Department of Chemical & Biochemical Engineering
    • Phone: 1.8484456686
    • Rutgers University
    • 599 Taylor Road
    • Piscataway, NJ 08854
    • Key Words: Gene-based therapeutics; bioinformatics and systems biology; hepatocyte differentiation; novel strategies for treatment of brain tumors
  • Roth, Monica

    • Monica Roth
    • Monica Roth
    • Professor
    • Department: Department of Pharmacology
    • Phone: 1.7322355048
    • Robert Wood Johnson Medical School Research Tower, Room 636
    • 675 Hoes Lane
    • Piscataway, NJ 08855
    • Key Words: Retroviruses: integration, reverse transcriptase, envelope proteins, gene therapy, targeted entry, structural studies
  • Runnels, Loren

    • Loren Runnels
    • Loren Runnels
    • Professor
    • Department: Department of Pharmacology
    • Program(s): Cell and Developmental Biology Graduate Program, Cellular and Molecular Pharmacology Graduate Program, Microbiology and Molecular Genetics Graduate Program, Physiology and Integrative Biology Graduate Program
    • Major Research Interest(s): Biochemistry, Stem Cells
    • Phone: 1.7322354593
    • Robert Wood Johnson Medical School
    • Research Tower, Fourth Floor, Room 402
    • 675 Hoes Lane West
    • Piscataway, NJ 08854
    • Key Words: Cancer, stem cells, development, cell death, signal transduction, ion transport, magnesium, calcium
  • Ryazanov, Alexey G

    • Alexey G. Ryazanov
    • Alexey G. Ryazanov
    • Professor
    • Department: Department of Pharmacology
    • Phone: 1.7322355526
    • Robert Wood Johnson Medical School, Room 443
    • 675 Hoes Lane
    • Piscataway, NJ 08854
    • Key Words: Novel protein kinases and signal transduction
  • Sarkar, Dipak

  • Schindler, Karen

  • Scotto, Kathleen

    • Kathleen W. Scotto
    • Kathleen W. Scotto
    • Professor
    • Department: Department of Pharmacology
    • Phone: 1.7322354812
    • Dean
    • Robert Wood Johnson Medical School
    • The Cancer Institute of NJ, Room 4558
    • 195 Little Albany Street
    • New Brunswick, NJ 08901
    • Key Words: Regulation of expression of drug resistance genes in human tumors
  • Shinbrot, Troy

    • Troy Shinbrot
    • Troy Shinbrot
    • Professor
    • Department: Department of Biomedical Engineering
    • Phone: 1.8484456584
    • Rutgers University
    • 599 Taylor Rd
    • Piscataway, NJ 08854
    • Key Words: Mechanisms for self-assembly in cells and in mixing problems
    • Lab Site URL
  • Shreiber, David I

  • Singson, Andrew

  • Snyder, Elizabeth

    • Elizabeth Snyder
    • Elizabeth Snyder
    • Assistant Professor
    • Department: Department of Animal Science
    • Phone: 1.8489326377
    • Rutgers University
    • School of Environmental and Biological Sciences
    • Foran Hall, Room 532
    • New Brunswick, NJ 08901
    • Key Words: Structural and nucleotide-level RNA variants, proteome composition, cellular development
  • Soto, Martha C

    • Martha C. Soto
    • Martha C. Soto
    • Professor
    • Department: Department of Pathology & Laboratory Medicine
    • Phone: 1.7322354424
    • Robert Wood Johnson Medical School
    • Research Tower - R232, 675 Hoes Lane
    • Piscataway, NJ 08854
    • Key Words: Cell Polarity, Embryonic Morphogenesis, Developmental Genetics, C. elegans
    • Lab Site URL
  • Stavropoulos, Nicholas

    • Nicholas Stavropoulos
    • Nicholas Stavropoulos
    • Associate Research Professor
    • Phone: 1.8484456495
    • Rutgers University
    • Waksman Institute of Microbiology
    • 190 Frelinghuysen Rd
    • Room 215
    • Piscataway, NJ 08854
    • Key Words: Sleep regulation, developmental neurobiology, neurogenesis, ubiquitin, autism
    • Lab Site URL