Program Faculty

The regulation of mRNA degradation plays a pivotal role in maintaining the delicate balance of gene expression and cellular function. Our research delves into the fascinating world of how cells fine-tune gene expression through the modulation of mRNA stability, with a particular focus on the intriguing process of decapping—the removal of the crucial 5´-end protective cap. This cap safeguards and significantly influences mRNA abundance and its expression. Over the years, we have made strides in identifying and characterizing the key components of mRNA decapping and linking them to various human disorders, resulting in impactful publications. Currently, our investigations are concentrated on three groundbreaking areas. First, we’re exploring the roles of two decapping enzymes in neurogenesis and cognitive function, using patient-derived induced pluripotent stem cells (iPSCs) differentiated into induced neurons (iNs). Our goal is to uncover the molecular mechanisms through which these enzymes affect neurogenesis. Second, we’ve discovered that mammalian RNA can harbor alternative caps—specifically, the NAD nucleotide metabolite—offering novel functions linking RNA metabolism to cellular metabolism. Lastly, we are unraveling new epitranscriptomic modifications on RNA that impact its intracellular compartmentalization and intercellular communication. Our current efforts aim to delineate how these modifications are added and regulated, providing insights into how they can be harnessed to influence gene expression and enhance cell-to-cell interactions.

Publications