Our research interest is to understand the alteration of important cancer-related signaling pathways in tumorigenesis, including the p53 and LIF signaling pathways. The recent research directions in my lab include: 1) the gain of oncogenic function of mutant p53 in cancers and its regulation; 2) the function of a multi-function cytokine LIF in cancer; 3) the regulation of metabolic reprogramming and tumor microenvironment, including immune function, by p53 and LIF on tumor development, progression and therapeutic responses.
Program Faculty
- Wenwei Hu
- Professor
- Department: Department of Radiation Oncology
- Graduate Program(s): Biochemistry | Cell and Developmental Biology | Cellular and Molecular Pharmacology | Microbiology and Molecular Genetics
- Major Research Interest(s): Cancer Biology, Disease genetics, Metabolism / Nutrition, Signaling, Stem Cells, Regeneration, and Tissue Injury
- Research Techniques: Biochemistry, Cell Biology, Genetics, Metabolomics, Transcriptomics
- Research Organism(s): Cell lines, Humans, Mice
- Rotation Faculty
- Phone: 1.7322356169
- Email:
This email address is being protected from spambots. You need JavaScript enabled to view it. - Robert Wood Johnson Medical School
- Cancer Institute of New Jersey CINJ, Room 3004
- 195 Little Albany Street
- New Brunswick, NJ 08903-2681
- Key Words: tumor suppressor and oncogene, tumorigenesis, p53, cytokine, cancer metabolism, tumor microenvironment
- Lab Site URL