Graduate Program in Biochemistry

Dr. Martin L. Yarmush is a physician-scientist, bioengineer, and translational investigator whose research integrates engineering, medicine, biology, and chemistry to develop new approaches for repairing, preserving, replacing, and regenerating tissues and organs. His laboratory has contributed broadly to tissue engineering, regenerative medicine, metabolic engineering, organ preservation, cell-based therapies, wound healing, microfabricated biomedical systems, and biomedical device development. A central theme of his work is the use of dynamic engineering principles to understand and control living systems across scales, from molecular and cellular metabolism to multicellular tissues, to perfused organs, to clinically relevant therapeutic platforms. Current research interests include ex vivo organ perfusion and preservation, strategies to improve the viability and function of marginal donor organs, engineered tissue and organ models, mitochondrial and metabolic regulation of injury and recovery, and image-guided robotic technologies for vascular access and point-of-care diagnostics. The overall goal of the laboratory is to create mechanistically grounded, clinically translatable technologies that address major unmet needs in transplantation, regenerative medicine,, chronic disease, and human health.

Publications